Structure of PDB 2gm1 Chain A

Receptor sequence
>2gm1A (length=327) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLKSSRKTYTF
DMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGE
RSPNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEEL
FDLLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGA
AKRTTAATLMNAYSSRSHSVFSVTIHMKEVKIGKLNLVDLAGSENIGRIN
QSLLTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPA
SLNLEETLSTLEYAHRAKNILNKPEVN
3D structure
PDB2gm1 Synthesis and SAR of pyrrolotriazine-4-one based Eg5 inhibitors.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A S232 S235 S214 S217
BS02 2AZ A E116 G117 E118 W127 I136 P137 Y211 L214 E215 R221 E98 G99 E100 W109 I118 P119 Y193 L196 E197 R203 MOAD: ic50=0.1uM
PDBbind-CN: -logKd/Ki=7.00,IC50=0.10uM
BindingDB: IC50=100nM
BS03 ADP A R26 P27 T107 G108 G110 K111 T112 F113 E118 R10 P11 T89 G90 G92 K93 T94 F95 E100
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:2gm1, PDBe:2gm1, PDBj:2gm1
PDBsum2gm1
PubMed16730979
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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