Structure of PDB 2glq Chain A

Receptor sequence

>2glqA (length=479) Species: 9606 (Homo sapiens)

IIPVEEENPDFWNREAAEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVT
AARILKGQKKDKLGPEIPLAMDRFPYVALSKTYNVDKHVPDSGATATAYL
CGVKGNFQTIGLSAAARFNQCNTTRGNEVISVMNRAKKAGKSVGVVTTTR
VQHASPAGTYAHTVNRNWYSDADVPASARQEGCQDIATQLISNMDIDVIL
GGGRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNR
TELMQASLDPSVTHLMGLFEPGDMKYEIHRDSTLDPSLMEMTEAALRLLS
RNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDT
LSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPGYV
LKDGARPDVTESESGSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVH
GVQEQTFIAHVMAFAACLEPYTACDLAPP

3D structure

• PDB: 2glq Structural studies of human alkaline phosphatase in complex with strontium: Implication for its secondary effect in bones.
• Chain: A
• Resolution: 1.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D42 S92 H153 S155 R166 E311 D316 H317 H320 D357 H358 H432
• Catalytic site (residue number reindexed from 1): D42 S92 H153 S155 R166 E311 D316 H317 H320 D357 H358 H432
• Enzyme Commision number: 3.1.3.1: alkaline phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	S92 D316 H320 H432	S92 D316 H320 H432
BS02	ZN	A	D42 S92 D357 H358	D42 S92 D357 H358
BS03	MG	A	D42 S155 E311	D42 S155 E311
BS04	SR	A	E216 F269 E270 D285	E216 F269 E270 D285

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004035 alkaline phosphatase activity
• GO:0005515 protein binding
• GO:0008270 zinc ion binding
• GO:0016787 hydrolase activity
• GO:0016791 phosphatase activity
• GO:0046872 metal ion binding

Cellular Component

• GO:0005886 plasma membrane
• GO:0009986 cell surface
• GO:0098552 side of membrane

External links

• PDB: RCSB:2glq, PDBe:2glq, PDBj:2glq
• PDBsum: 2glq
• PubMed: 16815919
• UniProt: P05187|PPB1_HUMAN Alkaline phosphatase, placental type (Gene Name=ALPP)