Structure of PDB 2gli Chain A

Receptor sequence

>2gliA (length=155) Species: 9606 (Homo sapiens)

ETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFK
AQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMC
EHEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHV
KTVHG

3D structure

• PDB: 2gli Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers.
• Chain: A
• Resolution: 2.6 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Y155 Y200 S215 K219 S246 R249	Y53 Y98 S113 K117 S144 R147
BS02	dna	A	R146 F151 K152 H160 Y181 R183 H220 T224 Y242 D244 S247 K250	R44 F49 K50 H58 Y79 R81 H118 T122 Y140 D142 S145 K148
BS03	CO	A	C106 C111 H124 H129	C4 C9 H22 H27
BS04	CO	A	C139 C144 H160 H164	C37 C42 H58 H62
BS05	CO	A	C172 C177 H190 H194	C70 C75 H88 H92
BS06	CO	A	C202 C207 H220 H225	C100 C105 H118 H123
BS07	CO	A	C233 C238 H251 H256	C131 C136 H149 H154

Gene Ontology

Molecular Function

• GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding

Biological Process

• GO:0006357 regulation of transcription by RNA polymerase II

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:2gli, PDBe:2gli, PDBj:2gli
• PDBsum: 2gli
• PubMed: 8378770
• UniProt: P08151|GLI1_HUMAN Zinc finger protein GLI1 (Gene Name=GLI1)