Structure of PDB 2gke Chain A

Receptor sequence
>2gkeA (length=274) Species: 727 (Haemophilus influenzae) [Search protein sequence]
MQFSKMHGLGNDFVVVDGVTQNVFFTPETIRRLANRHCGIGFDQLLIVEA
PYDPELDFHYRIFNADGSEVSQCGNGARCFARFVTLKGLTNKKDISVSTQ
KGNMVLTVKDDNQIRVNMGEPIWEPAKIPFTANKFEKNYILRTDIQTVLC
GAVSMGNPHCVVQVDDIQTANVEQLGPLLESHERFPERVNAGFMQIINKE
HIKLRVYERGAGETQACGSGACAAVAVGIMQGLLNNNVQVDLPGGSLMIE
WNGVGHPLYMTGEATHIYDGFITL
3D structure
PDB2gke Structural insights into stereochemical inversion by diaminopimelate epimerase: An antibacterial drug target.
ChainA
Resolution1.35 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C73 H159 E208 C217 G220
Catalytic site (residue number reindexed from 1) C73 H159 E208 C217 G220
Enzyme Commision number 5.1.1.7: diaminopimelate epimerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZDP A N11 F13 Q44 N64 V70 C73 G74 N75 N157 N190 E208 R209 C217 G218 S219 N11 F13 Q44 N64 V70 C73 G74 N75 N157 N190 E208 R209 C217 G218 S219
Gene Ontology
Molecular Function
GO:0008837 diaminopimelate epimerase activity
GO:0016853 isomerase activity
Biological Process
GO:0009085 lysine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:2gke, PDBe:2gke, PDBj:2gke
PDBsum2gke
PubMed16723397
UniProtP44859|DAPF_HAEIN Diaminopimelate epimerase (Gene Name=dapF)

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