Structure of PDB 2gk6 Chain A

Receptor sequence
>2gk6A (length=602) Species: 9606 (Homo sapiens) [Search protein sequence]
GSRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLNKKRI
AYFTLPLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSV
GAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGHE
VEDVIIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKT
VTSATIVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSR
EAIDSPVSFLALHNQIRNMDSMPELQKLQQLKDLSSADEKRYRALKRTAE
RELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLG
AKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYR
MHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQG
QEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYL
VQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRIGFLNDPRRL
NVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRES
LM
3D structure
PDB2gk6 Structural and functional insights into the human Upf1 helicase core
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PO4 A P494 K498 Q665 R703 R865 P195 K199 Q362 R400 R556
BS02 ADP A P469 D470 Q475 G497 K498 T499 V500 Y702 P170 D171 Q176 G198 K199 T200 V201 Y399
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:2gk6, PDBe:2gk6, PDBj:2gk6
PDBsum2gk6
PubMed17159905
UniProtQ92900|RENT1_HUMAN Regulator of nonsense transcripts 1 (Gene Name=UPF1)

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