Structure of PDB 2giw Chain A

Receptor sequence

>2giwA (length=104) Species: 9796 (Equus caballus)

GDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTD
ANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKK
ATNE

3D structure

• PDB: 2giw Solution structure of reduced horse heart cytochrome c.
• Chain: A
• Resolution: N/A

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	HEC	A	F10 C14 C17 H18 T28 P30 L35 T40 Y48 N52 W59 Y67 L68 K79 M80 F82 L94	F10 C14 C17 H18 T28 P30 L35 T40 Y48 N52 W59 Y67 L68 K79 M80 F82 L94

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008289 lipid binding
• GO:0009055 electron transfer activity
• GO:0020037 heme binding
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding

Biological Process

• GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
• GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
• GO:0006915 apoptotic process
• GO:0018063 cytochrome c-heme linkage
• GO:0043065 positive regulation of apoptotic process
• GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
• GO:2001056 positive regulation of cysteine-type endopeptidase activity

Cellular Component

• GO:0005739 mitochondrion
• GO:0005758 mitochondrial intermembrane space
• GO:0005829 cytosol
• GO:0070069 cytochrome complex

External links

• PDB: RCSB:2giw, PDBe:2giw, PDBj:2giw
• PDBsum: 2giw
• PubMed: 10499099
• UniProt: P00004|CYC_HORSE Cytochrome c (Gene Name=CYCS)