Structure of PDB 2giv Chain A

Receptor sequence
>2givA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
KYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFH
LGQCQWRQPPGKEIYRKSNISVHEVDGKDHKIYCQNLCLLAKLFLDHKTL
YFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRR
GYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLENLRSI
KDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLPPITVD
SVCLKWAP
3D structure
PDB2giv The Crystal Structure of Human MYST histone acetyltransferase 1 in complex with acetylcoenzyme A
ChainA
Resolution1.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C143 E177
Catalytic site (residue number reindexed from 1) C140 E174
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C37 C40 H53 C57 C34 C37 H50 C54
BS02 ACO A L98 C143 I144 L145 T146 Q151 R152 G154 G156 K157 L180 S181 L183 L186 S187 S190 L95 C140 I141 L142 T143 Q148 R149 G151 G153 K154 L177 S178 L180 L183 S184 S187
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2giv, PDBe:2giv, PDBj:2giv
PDBsum2giv
PubMed
UniProtQ9H7Z6|KAT8_HUMAN Histone acetyltransferase KAT8 (Gene Name=KAT8)

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