Structure of PDB 2giu Chain A

Receptor sequence
>2giuA (length=225) Species: 9606 (Homo sapiens) [Search protein sequence]
LDALSPEQLVLTLLEAEPPHVLISRPASMMMSLTKLADKELVHMISWAKK
IPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVLDRD
EGKCEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVAD
SSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNK
GMEHLLNMVVPVYDLLLEMLNAHVL
3D structure
PDB2giu The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FBR A L298 E305 I373 I376 F377 L33 E40 I107 I110 F111 MOAD: ic50=1.5nM
PDBbind-CN: -logKd/Ki=8.82,IC50=1.5nM
BindingDB: IC50=1.8nM,EC50=4nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:2giu, PDBe:2giu, PDBj:2giu
PDBsum2giu
PubMed16632357
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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