Structure of PDB 2ggd Chain A

Receptor sequence
>2ggdA (length=445) Species: 268951 (Agrobacterium sp. CP4) [Search protein sequence]
SSRPATARKSSGLSGTVRIPGDKSISHRSFMFGGLASGETRITGLLEGED
VINTGKAMQAMGARIRKEGDTWIIDGVGNGGLLAPEAPLDFGNAGTGCRL
TMGLVGVYDFDSTFIGDASLTKRPMGRVLNPLREMGVQVKSEDGDRLPVT
LRGPKTPTPITYRVPMASAQVKSAVLLAGLNTPGITTVIEPIMTRDHTEK
MLQGFGANLTVETDADGVRTIRLEGRGKLTGQVIDVPGDPSSTAFPLVAA
LLVPGSDVTILNVLMNPTRTGLILTLQEMGADIEVINPRLAGGEDVADLR
VRSSTLKGVTVPEDRAPSMIDEYPILAVAAAFAEGATVMNGLEELRVKES
DRLSAVANGLKLNGVDCDEGETSLVVRGRPDGKGLGNASGAAVATHLDHR
IAMSFLVMGLVSENPVTVDDATMIATSFPEFMDLMAGLGAKIELS
3D structure
PDB2ggd Molecular basis for the herbicide resistance of Roundup Ready crops.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K28 S29 D55 N98 R128 D326 E354 H404 R405 T431
Catalytic site (residue number reindexed from 1) K23 S24 D50 N93 R123 D321 E349 H399 R400 T426
Enzyme Commision number 2.5.1.19: 3-phosphoshikimate 1-carboxyvinyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S3P A S29 R33 T101 S173 Q175 R200 D326 K353 S24 R28 T96 S168 Q170 R195 D321 K348
BS02 GPJ A K28 G100 T101 R128 Q175 D326 E354 R357 H404 R405 K23 G95 T96 R123 Q170 D321 E349 R352 H399 R400 MOAD: ic50=160uM
PDBbind-CN: -logKd/Ki=3.80,IC50=160uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0009423 chorismate biosynthetic process
GO:0009635 response to herbicide
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ggd, PDBe:2ggd, PDBj:2ggd
PDBsum2ggd
PubMed16916934
UniProtQ9R4E4|AROA_AGRSC 3-phosphoshikimate 1-carboxyvinyltransferase (Gene Name=aroA)

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