Structure of PDB 2gg6 Chain A

Receptor sequence

>2gg6A (length=445) Species: 268951 (Agrobacterium sp. CP4)

SSRPATARKSSGLSGTVRIPGDKSISHRSFMFGGLASGETRITGLLEGED
VINTGKAMQAMGARIRKEGDTWIIDGVGNGGLLAPEAPLDFGNAATGCRL
TMGLVGVYDFDSTFIGDASLTKRPMGRVLNPLREMGVQVKSEDGDRLPVT
LRGPKTPTPITYRVPMASAQVKSAVLLAGLNTPGITTVIEPIMTRDHTEK
MLQGFGANLTVETDADGVRTIRLEGRGKLTGQVIDVPGDPSSTAFPLVAA
LLVPGSDVTILNVLMNPTRTGLILTLQEMGADIEVINPRLAGGEDVADLR
VRSSTLKGVTVPEDRAPSMIDEYPILAVAAAFAEGATVMNGLEELRVKES
DRLSAVANGLKLNGVDCDEGETSLVVRGRPDGKGLGNASGAAVATHLDHR
IAMSFLVMGLVSENPVTVDDATMIATSFPEFMDLMAGLGAKIELS

3D structure

• PDB: 2gg6 Molecular basis for the herbicide resistance of Roundup Ready crops.
• Chain: A
• Resolution: 1.64 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): K28 S29 D55 N98 R128 D326 E354 H404 R405 T431
• Catalytic site (residue number reindexed from 1): K23 S24 D50 N93 R123 D321 E349 H399 R400 T426
• Enzyme Commision number: 2.5.1.19: 3-phosphoshikimate 1-carboxyvinyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	S3P	A	S29 R33 T101 S173 Q175 D326 K353	S24 R28 T96 S168 Q170 D321 K348

Gene Ontology

Molecular Function

• GO:0003824 catalytic activity
• GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity
• GO:0016740 transferase activity
• GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups

Biological Process

• GO:0008652 amino acid biosynthetic process
• GO:0009073 aromatic amino acid family biosynthetic process
• GO:0009423 chorismate biosynthetic process
• GO:0009635 response to herbicide

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2gg6, PDBe:2gg6, PDBj:2gg6
• PDBsum: 2gg6
• PubMed: 16916934
• UniProt: Q9R4E4|AROA_AGRSC 3-phosphoshikimate 1-carboxyvinyltransferase (Gene Name=aroA)