Structure of PDB 2geb Chain A

Receptor sequence
>2gebA (length=184) Species: 119072 (Caldanaerobacter subterraneus subsp. tengcongensis) [Search protein sequence]
RGSHMPSPMEDIEEILITEEQLKAKVKELGEMITRDYEGKDLVLIGVLKG
AIMFMSGLSRAIDLPLSIDFLAVSSYGSSTKSSGIVKIIKDHDIDIEGKD
VLIVEDIIDSGLTLAYLRETLLGRKPRSLKICTILDKPERREADVKVDYC
GFKIPDKFVVGYGIDYAEKYRNLPFIGVLKPELY
3D structure
PDB2geb Crystal structure of Thermoanaerobacter tengcongensis hypoxanthine-guanine phosphoribosyl transferase L160I mutant--insights into inhibitor design.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E101 D102 D105 F154 R167
Catalytic site (residue number reindexed from 1) E105 D106 D109 F158 R171
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E101 D102 E105 D106
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2geb, PDBe:2geb, PDBj:2geb
PDBsum2geb
PubMed17662107
UniProtQ8R7L0

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