Structure of PDB 2gcd Chain A

Receptor sequence
>2gcdA (length=309) Species: 10116 (Rattus norvegicus) [Search protein sequence]
DPDVAELFFKDDPEKLFSDLREIGHGSFGAVYFARDVRNSEVVAIKKMSY
SGKQSNEKWQDIIKEVRFLQKLRHPNTIQYRGCYLREHTAWLVMEYCLGS
ASDLLEVHKKPLQEVEIAAVTHGALQGLAYLHSHNMIHRDVKAGNILLSE
PGLVKLGDFGSASIMAPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSL
GITCIELAERKPPLFNMNAMSALYHIAQNESPALQSGHWSEYFRNFVDSC
LQKIPQDRPTSEVLLKHRFVLRERPPTVIMDLIQRTKDAVRELDNLQYRK
MKKILFQEA
3D structure
PDB2gcd Crystal structure of the MAP3K TAO2 kinase domain bound by an inhibitor staurosporine.
ChainA
Resolution2.55 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 G155 N156 D169 P178 T185
Catalytic site (residue number reindexed from 1) D140 K142 G144 N145 D158 P167 T174
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 STU A I34 V42 A55 M105 Y107 C108 L109 G110 G155 L158 D169 K314 I23 V31 A44 M94 Y96 C97 L98 G99 G144 L147 D158 K303 PDBbind-CN: -logKd/Ki=5.52,IC50=3uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2gcd, PDBe:2gcd, PDBj:2gcd
PDBsum2gcd
PubMed16761096
UniProtQ9JLS3|TAOK2_RAT Serine/threonine-protein kinase TAO2 (Gene Name=Taok2)

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