Structure of PDB 2ga4 Chain A

Receptor sequence
>2ga4A (length=283) Species: 10730 (Escherichia phage 933W) [Search protein sequence]
REFTIDFSTQQSYVSSLNSIRTEISTPLEHISQGTTSVSVINHTPPGSYF
AVDIRGLDVYQARFDHLRLIIEQNNLYVAGFVNTATNTFYRFSDFTHISV
PGVTTVSMTTDSSYTTLQRVAALERSGMQISRHSLVSSYLALMEFSGNTM
TRDASRAVLRFVTVTAEALRFRQIQREFRQALSETAPVYTMTPGDVDLTL
NWGRISNVLPEYRGEDGVRVGRISFNNISAILGTVAVILNCHQPECQITG
DRPVIKINNTLWESNTAAAFLNRKSQFLYTTGK
3D structure
PDB2ga4 Binding of adenine to Stx2, the protein toxin from Escherichia coli O157:H7.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE A Y77 V78 S112 Y114 V162 R170 Y77 V78 S112 Y114 V162 R170
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
GO:0030598 rRNA N-glycosylase activity
GO:0090729 toxin activity
Biological Process
GO:0017148 negative regulation of translation
GO:0098676 modulation of host virulence by virus
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ga4, PDBe:2ga4, PDBj:2ga4
PDBsum2ga4
PubMed16820678
UniProtP09385|STXA_BP933 Shiga-like toxin 2 subunit A (Gene Name=stxA2)

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