Structure of PDB 2g8h Chain A

Receptor sequence
>2g8hA (length=136) Species: 86665 (Halalkalibacterium halodurans) [Search protein sequence]
EEIIWESLSVDVGSQGNPGIVEYKGVDTKTGEVLFEREPIPIGTNNMGEF
LAIVHGLRYLKERNSRKPIYSDSQTAIKWVKDKKAKSTLVRNEETALIWK
LVDEAEEWLNTHTYETPILKWQTDKWGEIKANYGRK
3D structure
PDB2g8h Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A N105 E109 D132 K180 T183 N45 E49 D72 K120 T123
BS02 dna A N77 P78 T104 N105 N106 Q134 K138 W139 S147 T148 N17 P18 T44 N45 N46 Q74 K78 W79 S87 T88
BS03 MG A D71 E109 D132 D11 E49 D72
BS04 MG A D71 N192 D11 N132
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2g8h, PDBe:2g8h, PDBj:2g8h
PDBsum2g8h
PubMed16601679
UniProtQ9KEI9|RNH1_HALH5 Ribonuclease H (Gene Name=rnhA)

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