Structure of PDB 2g1m Chain A

Receptor sequence
>2g1mA (length=211) Species: 9606 (Homo sapiens) [Search protein sequence]
LPALKLALEYIVPCMNKHGICVVDDFLGKETGQQIGDEVRALHDTGKFTD
GQLVSSKDIRGDKITWIEGKEPGCETIGLLMSSMDDLIRHCNGKLGSYKI
NGRTKAMVACYPGNGTGYVRHVDNPNGDGRCVTCIYYLNKDWDAKVSGGI
LRIFPEGKAQFADIEPKFDRLLFFWSDRRNPHEVQPAYATRYAITVWYFD
ADERARAKVKY
3D structure
PDB2g1m Cellular oxygen sensing: Crystal structure of hypoxia-inducible factor prolyl hydroxylase (PHD2).
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.29: hypoxia-inducible factor-proline dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE2 A H313 D315 H374 H121 D123 H182
BS02 4HG A M299 Y303 Y310 H313 Y329 L343 H374 V376 R383 M107 Y111 Y118 H121 Y137 L151 H182 V184 R191 BindingDB: IC50=1400nM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0031418 L-ascorbic acid binding

View graph for
Molecular Function
External links
PDB RCSB:2g1m, PDBe:2g1m, PDBj:2g1m
PDBsum2g1m
PubMed16782814
UniProtQ9GZT9|EGLN1_HUMAN Egl nine homolog 1 (Gene Name=EGLN1)

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