Structure of PDB 2fyf Chain A

Receptor sequence
>2fyfA (length=368) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
HLEIPTAIKPRDGRFGSGPSKVRLEQLQTLTTTAAALFGTSHRQAPVKNL
VGRVRSGLAELFSLPDGYEVILGNGGATAFWDAAAFGLIDKRSLHLTYGE
FSAKFASAVSKNPFVGEPIIITSDPGSAPEPQTDPSVDVIAWAHNETSTG
VAVAVRRPEGSDALVVIDATSGAGGLPVDIAETDAYYFAPQKNFASDGGL
WLAIMSPAALSRIEAIAATGRWVPDFLSLPIAVENSLKNQTYNTPAIATL
ALLAEQIDWLVGNGGLDWAVKRTADSSQRLYSWAQERPYTTPFVTDPGLR
SQVVGTIDFVDDVDAGTVAKILRANGIVDTEPYRKLGRNQLRVAMFPAVE
PDDVSALTECVDWVVERL
3D structure
PDB2fyf Structure of phosphoserine aminotransferase from Mycobacterium tuberculosis.
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F108 D176 K200
Catalytic site (residue number reindexed from 1) F101 D168 K192
Enzyme Commision number 2.6.1.52: phosphoserine transaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A A84 T85 W88 F108 T154 D176 T178 Q199 K200 A77 T78 W81 F101 T147 D168 T170 Q191 K192
BS02 PC4 A H8 L9 I329 A332 H1 L2 I321 A324
BS03 PLP A N251 T252 N243 T244
Gene Ontology
Molecular Function
GO:0004648 O-phospho-L-serine:2-oxoglutarate aminotransferase activity
GO:0004760 L-serine-pyruvate transaminase activity
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0006563 L-serine metabolic process
GO:0006564 L-serine biosynthetic process
GO:0008615 pyridoxine biosynthetic process
GO:0009058 biosynthetic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2fyf, PDBe:2fyf, PDBj:2fyf
PDBsum2fyf
PubMed22525753
UniProtP9WQ73|SERC_MYCTU Phosphoserine aminotransferase (Gene Name=serC)

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