Structure of PDB 2fxd Chain A

Receptor sequence
>2fxdA (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQITLWKRPIVTVKIGGQLKEALLDTGADDTVIEEMNLPGKWKPKIIGGI
GGFIKVRQYDQIIIEIAGHKAIGTVLVGPTPFNVIGRNLMTQIGATLNF
3D structure
PDB2fxd X-ray crystal structures of human immunodeficiency virus type 1 protease mutants complexed with atazanavir.
ChainA
Resolution1.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 3.1.26.13: retroviral ribonuclease H.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DR7 A L23 D25 G27 D29 G48 G49 I50 F82 V84 L23 D25 G27 D29 G48 G49 I50 F82 V84 MOAD: ic50=12nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2fxd, PDBe:2fxd, PDBj:2fxd
PDBsum2fxd
PubMed17537865
UniProtQ90HG9

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