Structure of PDB 2fv5 Chain A

Receptor sequence
>2fv5A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
ADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNT
AWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVK
MLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYGGSPRANSHGGVC
PKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEH
DPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESK
AQECFQERSNA
3D structure
PDB2fv5 IK682, a tight binding inhibitor of TACE.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.86: ADAM 17 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H405 H409 H415 H190 H194 H200
BS02 541 A T347 L348 G349 E398 L401 H405 E406 H409 H415 Y433 P437 V440 S441 N447 T132 L133 G134 E183 L186 H190 E191 H194 H200 Y218 P222 V225 S226 N232 MOAD: Ki~0.033nM
PDBbind-CN: -logKd/Ki=11.70,Kd<2pM
BindingDB: IC50=1nM
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2fv5, PDBe:2fv5, PDBj:2fv5
PDBsum2fv5
PubMed16762314
UniProtP78536|ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (Gene Name=ADAM17)

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