Structure of PDB 2fuv Chain A

Receptor sequence

>2fuvA (length=545) Species: 99287 (Salmonella enterica subsp. enterica serovar Typhimurium str. LT2)

AIHNRAGQPAQQSDLINVAQLTAQYYVLKPEAGNAEHAVKFGTSGHRGSA
GRHSFNEPHILAIAQAIAEERAKNGITGPCYVGKDTHALSEPAFISVLEV
LAANGVDVIVQENNGFTPTPAVSNAILVHNKKGGPLADGIVITPSHNPPE
DGGIKYNPPNGGPADTNVTKVVEDRANALLAGGLQGVKRISLDAAMASGH
VKAVDLVQPFVEGLADIVDMAAIQKAGLTLGVDPLGGSGIEYWKRIAEHY
KLNLTLVNDQVDQTFRFMHLDKDGAIRMDCSSECAMAGLLALRDKFDLAF
ANDPDYDRHGIVTPAGLMNPNHYLAVAINYLFQHRPLWGKDVAVGKTLVS
SAMIDRVVNDLGRKLVEVPVGFKWFVDGLFDGSFGFGGEESAGASFLRFD
GTPWSTDKDGIIMCLLAAEITAVTGKNPQEHYNELAARFGAPSYNRLQAS
ATSAQKAALSKLSPEMVSASTLAGDPITARLTAAPGNGASIGGLKVMTDN
GWFAARPSGTEDAYKIYCESFLGEEHRKQIEKEAVEIVSEVLKNA

3D structure

• PDB: 2fuv X-ray crystal structure of phosphoglucomutase from Salmonella typhimurium.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): S146 H147 D304 D306 D308 R309 K409
• Catalytic site (residue number reindexed from 1): S145 H146 D303 D305 D307 R308 K408
• Enzyme Commision number: 5.4.2.2: phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	S146 D304 D306 D308	S145 D303 D305 D307

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0004614 phosphoglucomutase activity
• GO:0016853 isomerase activity
• GO:0016868 intramolecular phosphotransferase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0005975 carbohydrate metabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:2fuv, PDBe:2fuv, PDBj:2fuv
• PDBsum: 2fuv
• UniProt: Q8ZQW9