Structure of PDB 2fsz Chain A

Receptor sequence
>2fszA (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]
SPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTKLADKELVHMISWA
KKIPGFVELSLFDQVRLLESSWMEVLMMGLMWRSIDHPGKLIFAPDLVLD
RDEGKSVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMSRK
LAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEH
LLNMNVVPVYDLLLEMLNAHVLR
3D structure
PDB2fsz A second binding site for hydroxytamoxifen within the coactivator-binding groove of estrogen receptor beta
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 OHT A M295 L298 T299 L301 A302 D303 E305 M336 G472 L476 M32 L35 T36 L38 A39 D40 E42 M73 G197 L201 BindingDB: IC50=20nM,Ki=0.16nM,EC50=32nM
BS02 OHT A L306 I310 K314 V328 L331 E332 W335 L43 I47 K51 V65 L68 E69 W72 BindingDB: IC50=20nM,Ki=0.16nM,EC50=32nM
External links
PDB RCSB:2fsz, PDBe:2fsz, PDBj:2fsz
PDBsum2fsz
PubMed16782818
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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