Structure of PDB 2fqt Chain A

Receptor sequence
>2fqtA (length=154) Species: 1423 (Bacillus subtilis) [Search protein sequence]
VESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPNKQAMKPDTI
HTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIVD
LLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELL
KVFG
3D structure
PDB2fqt Design and Synthesis of Substrate Analogue Inhibitors of S-Ribosylhomocysteinase (LuxS)
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.4.1.21: S-ribosylhomocysteine lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO A H54 H58 C126 H51 H55 C123
BS02 H1D A H54 E57 H58 A61 D78 I79 C126 G127 H51 E54 H55 A58 D75 I76 C123 G124 MOAD: Ki=0.72uM
PDBbind-CN: -logKd/Ki=6.14,Ki=0.72uM
BindingDB: Ki=720nM
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016829 lyase activity
GO:0043768 S-ribosylhomocysteine lyase activity
GO:0046872 metal ion binding
Biological Process
GO:0009372 quorum sensing

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Molecular Function
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Biological Process
External links
PDB RCSB:2fqt, PDBe:2fqt, PDBj:2fqt
PDBsum2fqt
PubMed16686542
UniProtO34667|LUXS_BACSU S-ribosylhomocysteine lyase (Gene Name=luxS)

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