Structure of PDB 2fme Chain A

Receptor sequence
>2fmeA (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]
KNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGSSRKTYTFDM
VFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFD
LLNPSSDVSERLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAK
RTTAATLMNAYSSRSHSVFSVTIHMKVKIGKLNLVDLAGSENIGRINQSL
LTLGRVITALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLN
LEETLSTLEYAHRAKNILNK
3D structure
PDB2fme Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3QC A E116 E118 R119 W127 D130 A133 I136 P137 Y211 L214 E215 E96 E98 R99 W107 D110 A113 I116 P117 Y191 L194 E195 MOAD: ic50=104nM
PDBbind-CN: -logKd/Ki=6.98,IC50=104nM
BindingDB: IC50=306nM
BS02 ADP A R24 P27 T107 G108 G110 K111 T112 F113 E118 R8 P11 T87 G88 G90 K91 T92 F93 E98
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:2fme, PDBe:2fme, PDBj:2fme
PDBsum2fme
PubMed16458511
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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