Structure of PDB 2fmb Chain A

Receptor sequence
>2fmbA (length=104) Species: 11665 (Equine infectious anemia virus) [Search protein sequence]
VTYNLEKRPTTIVLINDTPLNVLLDTGADTSVLTTAHYNRLKYRGRKYQG
TGIGGVGGNVETFSTPVTIKKKGRHIKTRMLVADIPVTILGRDILQDLGA
KLVL
3D structure
PDB2fmb Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LP1 A D25 G27 A28 D29 G54 P86 D25 G27 A28 D29 G54 P86 MOAD: Ki=2nM
PDBbind-CN: -logKd/Ki=8.70,Ki=2nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2fmb, PDBe:2fmb, PDBj:2fmb
PDBsum2fmb
PubMed9827997
UniProtQ66729

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