Structure of PDB 2fgu Chain A

Receptor sequence
>2fguA (length=99) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
PQITLWKRPLVTIRIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGI
GGFIKVRQYDQIPVEICGHKAIGTVLVGPSPVNIIGRNLLTQIGCTLNF
3D structure
PDB2fgu Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D25 T26 G27
Catalytic site (residue number reindexed from 1) D25 T26 G27
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ASN A D30 G48 D30 G48 PDBbind-CN: -logKd/Ki=9.18,Kd=0.66nM
BS02 HPH A D25 G27 G49 I50 D25 G27 G49 I50 PDBbind-CN: -logKd/Ki=9.18,Kd=0.66nM
BS03 DIQ A D25 I84 D25 I84 PDBbind-CN: -logKd/Ki=9.18,Kd=0.66nM
Gene Ontology
Molecular Function
GO:0004190 aspartic-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:2fgu, PDBe:2fgu, PDBj:2fgu
PDBsum2fgu
PubMed16809296
UniProtP03369|POL_HV1A2 Gag-Pol polyprotein (Gene Name=gag-pol)

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