Structure of PDB 2fdk Chain A

Receptor sequence
>2fdkA (length=198) Species: 83333 (Escherichia coli K-12) [Search protein sequence]
AAGAVILRRFAFNAAEQLIRDINDVASQSPFRQMVTPGGYTMSVAMTNCG
HLGWTTHRQGYLYSPIDPQTNKPWPAMPQSFHNLCQRAATAAGYPDFQPD
ACLINRYAPGAKLSLHQDKDEPDLRAPIVSVSLGLPAIFQFGGLKRNDPL
KRLLLEHGDVVVWGGESRLFYHGIQPLKAGFHPLTIDCRYNLTFRQAG
3D structure
PDB2fdk Crystal structures of catalytic complexes of the oxidative DNA/RNA repair enzyme AlkB.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.11.33: DNA oxidative demethylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A T51 P52 T56 M57 W69 Y76 L128 S129 H131 D133 R161 R210 T36 P37 T41 M42 W54 Y61 L113 S114 H116 D118 R146 R195
BS02 FE2 A H131 D133 H187 G213 H116 D118 H172 G198
BS03 AKG A N120 Y122 L128 H131 H187 I189 R204 N206 N105 Y107 L113 H116 H172 I174 R189 N191
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0035515 oxidative RNA demethylase activity
GO:0035516 broad specificity oxidative DNA demethylase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006281 DNA repair
GO:0006307 DNA alkylation repair
GO:0035513 oxidative RNA demethylation
GO:0042245 RNA repair
GO:0070989 oxidative demethylation
GO:0072702 response to methyl methanesulfonate
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:2fdk, PDBe:2fdk, PDBj:2fdk
PDBsum2fdk
PubMed16482161
UniProtP05050|ALKB_ECOLI Alpha-ketoglutarate-dependent dioxygenase AlkB (Gene Name=alkB)

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