Structure of PDB 2fb2 Chain A

Receptor sequence
>2fb2A (length=327) Species: 1280 (Staphylococcus aureus) [Search protein sequence]
EQIKDKLGRPIRDLALSVTDRCNFRCDYCMPKEVFGDDFVFLPKNELLTF
DEMARIAKVYAELGVKKIRITGGEPLMRRDLDVLIAKLNQIDGIEDIGLT
TNGLLLKKHGQKLYDAGLRRINVSLDAIDDTLFQSINNRNIKATTILEQI
DYATSIGLNVKVNVVIQKGINDDQIIPMLEYFKDKHIEIRFIEFMDVGND
NGWDFSKVVTKDEMLTMIEQHFEIDPVEPKYFGEVAKYYRHKDNGVQFGL
ITSVSQSFCSTCTAAALSSDGKFYGCLFATVDGFNVKAFIRSGVTDEELK
EQFKALWQIRDDRYSDERTAQTVANRQ
3D structure
PDB2fb2 Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.1.99.22: GTP 3',8-cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAM A Y30 T73 G75 E76 T102 T103 S126 V167 M197 Y28 T71 G73 E74 T100 T101 S124 V165 M195
BS02 SF4 A C24 F26 C28 C31 M32 G75 C22 F24 C26 C29 M30 G73
BS03 SF4 A C261 C264 C278 R312 S317 C259 C262 C276 R310 S315
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005525 GTP binding
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0061798 GTP 3',8'-cyclase activity
GO:0061799 cyclic pyranopterin monophosphate synthase activity
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0006777 Mo-molybdopterin cofactor biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:2fb2, PDBe:2fb2, PDBj:2fb2
PDBsum2fb2
PubMed16632608
UniProtP69848|MOAA_STAA8 GTP 3',8-cyclase (Gene Name=moaA)

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