Structure of PDB 2fai Chain A

Receptor sequence
>2faiA (length=236) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB2fai Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E542 I54 K58 L68 V72 E230
BS02 459 A M343 L346 E353 H524 M39 L42 E49 H212 MOAD: Ki=570nM
PDBbind-CN: -logKd/Ki=6.24,Ki=570nM
External links
PDB RCSB:2fai, PDBe:2fai, PDBj:2fai
PDBsum2fai
PubMed16648639
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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