Structure of PDB 2f8s Chain A

Receptor sequence
>2f8sA (length=704) Species: 63363 (Aquifex aeolicus) [Search protein sequence]
KEALLNLYRIEYRPKDTTFTVFKPTHEIQKEKLNKVRWRVFLQTGLPTFR
REDEFWCAGKVEKDTLYLTLSNGEIVELKRVGEEEFRGFQNERECQELFR
DFLTKTKVKDKFISDFYKKFRDKITVQGKNRKIALIPEVNEKVLKSEEGY
FLLHLDLKFRIQPFETLQTLLERNDFNPKRIRVKPIGIDFVGRVQDVFKA
KEKGEEFFRLCMERSTHKSSKKAWEELLKNRELREKAFLVVLEKGYTYPA
TILKPVLTYENLEDEERNEVADIVRMEPGKRLNLIRYILRRYVKALRDYG
WYISPEEERAKGKLNFKDTVLDAKGKNTKVITNLRKFLELCRPFVKKDVL
SVEIISVSVYKKLEWRKEEFLKELINFLKNKGIKLKIKGKSLILAQTREE
AKEKLIPVINKIKDVDLVIVFLEEYPKVDPYKSFLLYDFVKRELLKKMIP
SQVILNRTLKNENLKFVLLNVAEQVLAKTGNIPYKLKEIEGKVDAFVGID
ISRITRDGKTVNAVAFTKIFNSKGELVRYYLTSYPAFGEKLTEKAIGDVF
SLLEKLGFKKGSKIVVHRDGRLYRDEVAAFKKYGELYGYSLELLEIIKRN
NPRFFSNEKFIKGYFYKLSEDSVILATYNQVYEGTHQPIKVRKVYGELPV
EVLCSQILSLTLMNYSSFQPIKLPATVHYSDKITKLMLRGIEPIKKEGDI
MYWL
3D structure
PDB2f8s A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.1.26.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A D112 I115 Y119 R123 I138 I188 G189 I190 D191 K256 D110 I113 Y117 R121 I136 I186 G187 I188 D189 K254
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2f8s, PDBe:2f8s, PDBj:2f8s
PDBsum2f8s
PubMed17027504
UniProtO67434|AGO_AQUAE Protein argonaute (Gene Name=ago)

[Back to BioLiP]