Structure of PDB 2f8f Chain A

Receptor sequence
>2f8fA (length=203) Species: 6185 (Schistosoma haematobium) [Search protein sequence]
DHIKVIFFNGRGRAESIRMTLVAAGVNYEDERISFQDWPKIKPTIPGGRL
PAVKITDNHGHVKWMVESLAIARYMAKKHHMMGGTEEEYYNVEKLIGQAE
DLEHEYYKTLMKPEEEKQKIIKEILNGKVPVLLDIICESLKASTGKLAVG
DKVTLADLVLIAVIDHVTDLDKEFLTGKYPEIHKHRENLLASSPRLAKYL
SDR
3D structure
PDB2f8f Probing the Mechanism of GSH Activation in Schistosoma haematobium Glutathione-S-transferase by Site-directed Mutagenesis and X-ray Crystallography.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) F10 R16 R21
Catalytic site (residue number reindexed from 1) F7 R13 R18
Enzyme Commision number 2.5.1.18: glutathione transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GSH A F11 R16 W41 K45 R52 L53 E70 S71 F8 R13 W38 K42 R49 L50 E67 S68 MOAD: Kd=21uM
Gene Ontology
Molecular Function
GO:0004364 glutathione transferase activity
GO:0016740 transferase activity
Biological Process
GO:0006749 glutathione metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2f8f, PDBe:2f8f, PDBj:2f8f
PDBsum2f8f
PubMed16777141
UniProtP30113|GST28_SCHHA Glutathione S-transferase class-mu 28 kDa isozyme

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