Structure of PDB 2f2p Chain A

Receptor sequence

>2f2pA (length=169) Species: 9913 (Bos taurus)

DQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDM
INEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYIS
AAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAAAAR
KEVIRNKIRAIGKMARVFS

3D structure

• PDB: 2f2p Structure of calmodulin bound to a calcineurin Peptide: a new way of making an old binding mode.
• Chain: A
• Resolution: 2.6 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): V35
• Catalytic site (residue number reindexed from 1): V34
• Enzyme Commision number:
  3.1.3.16: protein-serine/threonine phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	D20 D22 D24 T26 E31	D19 D21 D23 T25 E30
BS02	CA	A	D56 D58 N60 T62 E67	D55 D57 N59 T61 E66
BS03	CA	A	D93 D95 N97 Y99 I100 E104	D92 D94 N96 Y98 I99 E103
BS04	CA	A	D129 D131 D133 Q135 E140	D128 D130 D132 Q134 E139

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding
• GO:0005515 protein binding
• GO:0019904 protein domain specific binding
• GO:0046872 metal ion binding

Biological Process

• GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
• GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity
• GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity

Cellular Component

• GO:0000922 spindle pole
• GO:0005737 cytoplasm
• GO:0005819 spindle
• GO:0005829 cytosol
• GO:0005856 cytoskeleton
• GO:0032991 protein-containing complex

External links

• PDB: RCSB:2f2p, PDBe:2f2p, PDBj:2f2p
• PDBsum: 2f2p
• PubMed: 16411749
• UniProt: P48452|PP2BA_BOVIN Protein phosphatase 3 catalytic subunit alpha (Gene Name=PPP3CA);
  P62157|CALM_BOVIN Calmodulin (Gene Name=CALM)