Structure of PDB 2ex9 Chain A

Receptor sequence
>2ex9A (length=442) Species: 562 (Escherichia coli) [Search protein sequence]
TQLPAGANLALMVQKVGASAPAIDYHSQQMALPASTQKVITALAALIQLG
PDFRFTTTLETKGNVENGVLKGDLVARFGADPTLKRQDIRNMVATLKKSG
VNQIDGNVLIDTSIFASHDKAPGWPWNDMTQCFSAPPAAAIVDRNCFSVS
LYSAPKPGDMAFIRVASYYPVTMFSQVRTLPRGSAEAQYCELDVVPGDLN
RFTLTGCLPQRSEPLPLAFAVQDGASYAGAILKYELKQAGITWSGTLLRQ
TQVNEPGTVVASKQSAPLHDLLKIMLKKSDNMIADTVFRMIGHARFNVPG
TWRAGSDAVRQILRQQAGVDIGNTIIADGSGLSRHNLIAPATMMQVLQYI
AQHDNELNFISMLPLAGYDGSLQYRAGLHQAGVDGKVSAKTGSLQGVYNL
AGFITTASGQRMAFVQYLSGYAVEIPLVRFESRLYKDIYQNN
3D structure
PDB2ex9 Crystal structure of penicillin binding protein 4 (dacB) from Escherichia coli, both in the native form and covalently linked to various antibiotics
ChainA
Resolution1.65 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
3.4.21.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 35P A S62 S306 N308 S420 L421 S35 S279 N281 S393 L394
Gene Ontology
Molecular Function
GO:0004175 endopeptidase activity
GO:0004180 carboxypeptidase activity
GO:0004185 serine-type carboxypeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005515 protein binding
GO:0008658 penicillin binding
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
GO:0016787 hydrolase activity
Biological Process
GO:0000270 peptidoglycan metabolic process
GO:0006508 proteolysis
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0043093 FtsZ-dependent cytokinesis
GO:0046677 response to antibiotic
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane
GO:0042597 periplasmic space

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Cellular Component
External links
PDB RCSB:2ex9, PDBe:2ex9, PDBj:2ex9
PDBsum2ex9
PubMed16411754
UniProtP24228|DACB_ECOLI D-alanyl-D-alanine carboxypeptidase DacB (Gene Name=dacB)

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