Structure of PDB 2ewp Chain A

Receptor sequence
>2ewpA (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
PYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGW
AKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIM
DEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHI
EDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAV
QHFYNIKLEGKVPMHKLFLEMLEA
3D structure
PDB2ewp Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TXF A C269 A272 D273 E275 L309 V313 Y326 N346 F435 L440 E441 C37 A40 D41 E43 L77 V81 Y94 N114 F203 L208 E209 MOAD: ic50=0.079uM
PDBbind-CN: -logKd/Ki=7.10,IC50=0.079uM
BindingDB: IC50=77nM
External links
PDB RCSB:2ewp, PDBe:2ewp, PDBj:2ewp
PDBsum2ewp
PubMed16307879
UniProtP62508|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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