Structure of PDB 2evl Chain A

Receptor sequence

>2evlA (length=205) Species: 9606 (Homo sapiens)

LAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNI
TKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRF
IQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALY
AAPYKSDFLKALSKQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAE
LNYKV

3D structure

• PDB: 2evl The liganding of glycolipid transfer protein is controlled by glycolipid acyl structure.
• Chain: A
• Resolution: 2.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GAL	A	D48 N52 W96 Y207	D45 N49 W93 Y203	PDBbind-CN: -logKd/Ki=6.70,Kd=0.2uM
BS02	SPH	A	D48 W96 I147	D45 W93 I144	PDBbind-CN: -logKd/Ki=6.70,Kd=0.2uM
BS03	EIC	A	F34 I45 D48 W96 F103 F107 L136 F148	F31 I42 D45 W93 F100 F104 L133 F145	PDBbind-CN: -logKd/Ki=6.70,Kd=0.2uM

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008289 lipid binding
• GO:0017089 glycolipid transfer activity
• GO:0042802 identical protein binding
• GO:0051861 glycolipid binding
• GO:0120013 lipid transfer activity
• GO:1902387 ceramide 1-phosphate binding
• GO:1902388 ceramide 1-phosphate transfer activity

Biological Process

• GO:0006869 lipid transport
• GO:0035627 ceramide transport
• GO:0035902 response to immobilization stress
• GO:0046836 glycolipid transport
• GO:0120009 intermembrane lipid transfer
• GO:1902389 ceramide 1-phosphate transport

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:2evl, PDBe:2evl, PDBj:2evl
• PDBsum: 2evl
• PubMed: 17105344
• UniProt: Q9NZD2|GLTP_HUMAN Glycolipid transfer protein (Gene Name=GLTP)