Structure of PDB 2eud Chain A

Receptor sequence
>2eudA (length=648) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TTKQFSKVVEDLYRYVNAATGKPAPMISDDVYNIVMENKDKLNSAIVYDR
DFQYSYFGFKTLERSYLLRINGQVAERPQHLIMRVALGIHGRDIEAALET
YNLMSLKYFTHASPTLFNAGTPKPQMSSCFLVAMKEDSIEGIYDTLKECA
LISKTAGGIGLHIHNIRSTGSYIAGTNGTSNGLIPMIRVFNNTARYVDQG
GNKRPGAFALYLEPWHADIFDFIDIRKNHGKEEIRARDLFPALWIPDLFM
KRVEENGTWTLFSPTSAPGLSDCYGDEFEALYTRYEKEGRGKTIKAQKLW
YSILEAQTETGTPFVVYKDACNRKSNQKNLGVIKSSNLCCEIVEYSAPDE
TAVCNLASVALPAFIETSEDGKTSTYNFKKLHEIAKVVTRNLNRVIDRNY
YPVEEARKSNMRHRPIALGVQGLADTFMLLRLPFDSEEARLLNIQIFETI
YHASMEASCELAQKDGPYETFQGSPASQGILQFDMWDQKPYGMWDWDTLR
KDIMKHGVRNSLTMAPMPTASTSQILGYNECFEPVTSNMFQVVNPYLLRD
LVDLGIWDEGMKQYLITQNGSIQGLPNVPQELKDLYKTVWEISQKTIINM
AADRSVYIDQSHSLNLFLRAPTMGKLTSMHFYGWKKGLKTGMYYLRTQ
3D structure
PDB2eud Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C218 N426 C428 E430 C443 Y741 Y742
Catalytic site (residue number reindexed from 1) C129 N337 C339 E341 C354 Y643 Y644
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A D226 S227 I228 I231 R256 I262 A263 D137 S138 I139 I142 R167 I173 A174
BS02 GCQ A A201 S202 F206 S217 C218 G246 G247 R293 L427 C428 M606 P607 T608 A609 S610 T611 A112 S113 F117 S128 C129 G157 G158 R204 L338 C339 M517 P518 T519 A520 S521 T522
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
Biological Process
GO:0009263 deoxyribonucleotide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2eud, PDBe:2eud, PDBj:2eud
PDBsum2eud
PubMed16537480
UniProtP21524|RIR1_YEAST Ribonucleoside-diphosphate reductase large chain 1 (Gene Name=RNR1)

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