Structure of PDB 2eq8 Chain A

Receptor sequence
>2eq8A (length=460) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MKTYDLIVIGTGPGGYHAAIRAAQLGLKVLAVEAGEVGGVCLNVGCIPTK
ALLHAAETLHHLKVAEGFGLKAKPELDLKKLGGWRDQVVKKLTGGVGTLL
KGNGVELLRGFARLVGPKEVEVGGERYGAKSLILATGSEPLELKGFPFGE
DVWDSTRALKVEEGLPKRLLVIGGGAVGLELGQVYRRLGAEVTLIEYMPE
ILPQGDPETAALLRRALEKEGIRVRTKTKAVGYEKKKDGLHVRLEPAEGG
EGEEVVVDKVLVAVGRKPRTEGLGLEKAGVKVDERGFIRVNARMETSVPG
VYAIGDAARPPLLAHKAMREGLIAAENAAGKDSAFDYQVPSVVYTSPEWA
GVGLTEEEAKRAGYKVKVGKFPLAASGRALTLGGAEGMVKVVGDEETDLL
LGVFIVGPQAGELIAEAALALEMGATLTDLALTVHPHPTLSESLMEAAEA
FHKQAIHILN
3D structure
PDB2eq8 Crystal structure of lipoamide dehydrogenase from Thermus thermophilus HB8
ChainA
Resolution1.94 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) V43 C47 C52 T55 A186 E190 H444 H446 E451 N469
Catalytic site (residue number reindexed from 1) V37 C41 C46 T49 A176 E180 H435 H437 E442 N460
Enzyme Commision number 1.8.1.4: dihydrolipoyl dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A I15 G16 G18 P19 G20 E39 A40 G45 V46 C47 G51 C52 K56 F118 A119 A146 T147 G148 S166 R277 D314 L320 L321 A322 H323 Y353 I9 G10 G12 P13 G14 E33 A34 G39 V40 C41 G45 C46 K50 F111 A112 A135 T136 G137 S155 R269 D306 L312 L313 A314 H315 Y344
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004148 dihydrolipoyl dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0050660 flavin adenine dinucleotide binding

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Molecular Function
External links
PDB RCSB:2eq8, PDBe:2eq8, PDBj:2eq8
PDBsum2eq8
PubMed
UniProtQ5SLR0

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