Structure of PDB 2en5 Chain A

Receptor sequence
>2en5A (length=265) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MVLYFIGLGLYDERDITVKGLEIAKKCDYVFAEFYTSLMAGTTLGRIQKL
IGKEIRVLSREDVELNFENIVLPLAKENDVAFLTPGDPLVATTHAELRIR
AKRAGVESYVIHAPSIYSAVGITGLHIYKFGKSATVAYPEGNWFPTSYYD
VIKENAERGLHTLLFLDIKAEKRMYMTANEAMELLLKVEDMKKGGVFTDD
TLVVVLARAGSLNPTIRAGYVKDLIREDFGDPPHILIVPGKLHIVEAEYL
VEIAGAPREILHVNV
3D structure
PDB2en5 Mutant R262H structure of PH0725 from Pyrococcus horikoshii OT3
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.98: diphthine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A L10 T36 S37 G86 D87 V90 S115 I116 F165 L166 A209 P233 H234 I235 L10 T36 S37 G86 D87 V90 S115 I116 F165 L166 A209 P233 H234 I235
Gene Ontology
Molecular Function
GO:0004164 diphthine synthase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0017183 protein histidyl modification to diphthamide
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:2en5, PDBe:2en5, PDBj:2en5
PDBsum2en5
PubMed
UniProtO58456|DPHB_PYRHO Diphthine synthase (Gene Name=dphB)

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