Structure of PDB 2ek3 Chain A

Receptor sequence
>2ek3A (length=264) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
VMYFIGLGLYDERDITVKGLEIAKKCDYVFAEFYTSLMAGTTLGRIQKLI
GKEIRVLSREDVELNFENIVLPLAKENDVAFLTPGDPLVATTHAELRIRA
KRAGVESYVIHAPSIYSAVGITGLHIYKFGKSATVAYPEGNWFPTSYYDV
IKENAERGLHTLLFLDIKAEKRMYMTANEAMELLLKVEDMKKGGVFTDDT
LVVVLARAGSLNPTIRAGYVKDLIREDFGDPPHILIVPGKLHIVEAEYLV
EIAGAPREILRVNV
3D structure
PDB2ek3 Structural study of Project ID PH0725 from Pyrococcus horikoshii OT3 (L3M)
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.98: diphthine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A L10 T36 S37 G86 D87 V90 A91 S115 I116 F165 L166 A209 P233 H234 I235 L9 T35 S36 G85 D86 V89 A90 S114 I115 F164 L165 A208 P232 H233 I234
Gene Ontology
Molecular Function
GO:0004164 diphthine synthase activity
GO:0008168 methyltransferase activity
Biological Process
GO:0017183 protein histidyl modification to diphthamide
GO:0032259 methylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2ek3, PDBe:2ek3, PDBj:2ek3
PDBsum2ek3
PubMed
UniProtO58456|DPHB_PYRHO Diphthine synthase (Gene Name=dphB)

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