Structure of PDB 2ejv Chain A

Receptor sequence

>2ejvA (length=343) Species: 300852 (Thermus thermophilus HB8)

MRALAKLAPEEGLTLVDRPVPEPGPGEILVRVEAASICGTDLHIWKWDAW
ARGRIRPPLVTGHEFSGVVEAVGPGVRRPQVGDHVSLESHIVCHACPACR
TGNYHVCLNTQILGVDRDGGFAEYVVVPAENAWVNPKDLPFEVAAILEPF
GNAVHTVYAGSGVSGKSVLITGAGPIGLMAAMVVRASGAGPILVSDPNPY
RLAFARPYADRLVNPLEEDLLEVVRRVTGSGVEVLLEFSGNEAAIHQGLM
ALIPGGEARILGIPSDPIRFDLAGELVMRGITAFGIAGRRLWQTWMQGTA
LVYSGRVDLSPLLTHRLPLSRYREAFGLLASGQAVKVILDPKA

3D structure

• PDB: 2ejv Crystal structure of threonine 3-dehydrogenase
• Chain: A
• Resolution: 2.55 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): C38 G39 T40 H43 H63 E64 C93 C96 C99 C107 Q111 P149 A153 K336
• Catalytic site (residue number reindexed from 1): C38 G39 T40 H43 H63 E64 C93 C96 C99 C107 Q111 P149 A153 K336
• Enzyme Commision number: 1.1.1.103: L-threonine 3-dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C38 H63 E64	C38 H63 E64
BS02	ZN	A	C96 C99 C107	C96 C99 C107
BS03	NAD	A	G172 G174 P175 I176 S195 D196 P197 R201 F238 S239 N241 A244 L261 G262 I263	G172 G174 P175 I176 S195 D196 P197 R201 F238 S239 N241 A244 L261 G262 I263

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0008743 L-threonine 3-dehydrogenase activity
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006567 threonine catabolic process
• GO:0019518 L-threonine catabolic process to glycine

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2ejv, PDBe:2ejv, PDBj:2ejv
• PDBsum: 2ejv
• UniProt: Q5SKS4|TDH_THET8 L-threonine 3-dehydrogenase (Gene Name=tdh)