Structure of PDB 2egd Chain A

Receptor sequence

>2egdA (length=86) Species: 9606 (Homo sapiens) [Search protein sequence]

PLTELEESIETVVTTFFTFARQEGRKDSLSVNEFKELVTQQLPHLLKDVG
SLDEKMKSLDVNQDSELKFNEYWRLIGELAKEIRKK

3D structure

PDB

2egd Crystal structure of human S100A13 in the Ca2+-bound state

Chain

Resolution

1.8 Å

3D
structure

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	A24 E27 R29 S32 E37	A20 E23 R25 S28 E33
BS02	CA	A	D64 N66 D68 E70 E75	D60 N62 D64 E66 E71

Gene Ontology

	Molecular Function
GO:0005507	copper ion binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0008289	lipid binding
GO:0017134	fibroblast growth factor binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0048306	calcium-dependent protein binding
GO:0050786	RAGE receptor binding

	Biological Process
GO:0001819	positive regulation of cytokine production
GO:0008284	positive regulation of cell population proliferation
GO:0015031	protein transport
GO:0032730	positive regulation of interleukin-1 alpha production
GO:0043123	positive regulation of canonical NF-kappaB signal transduction
GO:0043303	mast cell degranulation

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0048471	perinuclear region of cytoplasm

External links

PDB	RCSB:2egd, PDBe:2egd, PDBj:2egd
PDBsum	2egd
PubMed	18259052
UniProt	Q99584\|S10AD_HUMAN Protein S100-A13 (Gene Name=S100A13)