Structure of PDB 2eco Chain A

Receptor sequence
>2ecoA (length=302) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
MRVEGAIGKTPVVRLAKVVEPDMAEVWVKLEGLNPGGSIKDRPAWYMIKD
AEERGILRPGSGQVIVEPTSGNTGIGLAMIAASRGYRLILTMPAQMSEER
KRVLKAFGAELVLTDPERRMLAAREEALRLKEELGAFMPDQFKNPANVRA
HYETTGPELYEALEGRIDAFVYGSGTGGTITGVGRYLKERIPHVKVIAVE
PARSNVLSGGKMGQHGFQGMGPGFIPENLDLSLLDGVIQVWEEDAFPLAR
RLAREEGLFLGMSSGGIVWAALQVARELGPGKRVACISPDGGWKYLSTPL
YA
3D structure
PDB2eco Crystal Structure of T.th. HB8 O-acetylserine sulfhydrylase Complexed with 4-methylvalerate
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K40 S70 E200 S204 S263
Catalytic site (residue number reindexed from 1) K40 S70 E200 S204 S263
Enzyme Commision number 2.5.1.47: cysteine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A K40 N72 Y172 G175 T176 T179 G219 S263 P289 D290 K40 N72 Y172 G175 T176 T179 G219 S263 P289 D290
BS02 4MV A K40 T69 G71 T73 Q141 G175 T176 G219 K40 T69 G71 T73 Q141 G175 T176 G219
Gene Ontology
Molecular Function
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0019344 cysteine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:2eco, PDBe:2eco, PDBj:2eco
PDBsum2eco
PubMed
UniProtQ5SLE6

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