Structure of PDB 2ec0 Chain A

Receptor sequence

>2ec0A (length=470) Species: 244367 (Foot-and-mouth disease virus C-S8c1)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDA

3D structure

• PDB: 2ec0 Sequential structures provide insights into the fidelity of RNA replication
• Chain: A
• Resolution: 2.75 Å

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	L108 D109 E112 T115 A116 V181 R193 H204 G216 C217 N218 S298 G299 C300 S301 Y336	L108 D109 E112 T115 A116 V181 R193 H204 G216 C217 N218 S298 G299 C300 S301 Y336
BS02	rna	A	S304 Y336 D338 D339 L386 K387 R388 I411 R416 E422 K423 S426	S304 Y336 D338 D339 L386 K387 R388 I411 R416 E422 K423 S426
BS03	MG	A	D238 D339 T384	D238 D339 T384

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:2ec0, PDBe:2ec0, PDBj:2ec0
• PDBsum: 2ec0
• PubMed: 17517631
• UniProt: Q9QCE4