Structure of PDB 2e9z Chain A

Receptor sequence

>2e9zA (length=476) Species: 244367 (Foot-and-mouth disease virus C-S8c1)

GLIVDTRDVEERVHVMRKTKLAPTVAHGVFNPEFGPAALSNKDPRLNEGV
VLDEVIFSKHKGDTKMSAEDKALFRRCAADYASRLHSVLGTANAPLSIYE
AIKGVDGLDAMEPDTAPGLPWALQGKRRGALIDFENGTVGPEVEAALKLM
EKREYKFACQTFLKDEIRPMEKVRAGKTRIVDVLPVEHILYTRMMIGRFC
AQMHSNNGPQIGSAVGCNPDVDWQRFGTHFAQYRNVWDVDYSAFDANHCS
DAMNIMFEEVFRTEFGFHPNAEWILKTLVNTEHAYENKRITVEGGMPSGC
SATSIINTILNNIYVLYALRRHYEGVELDTYTMISYGDDIVVASDYDLDF
EALKPHFKSLGQTITPADKSDKGFVLGHSITDVTFLKRHFHMDYGTGFYK
PVMASKTLEAILSFARRGTIQEKLISVAGLAVHSGPDEYRRLFEPFQGLF
EIPSYRSLYLRWVNAVCGDAAALEHH

3D structure

• PDB: 2e9z Sequential structures provide insights into the fidelity of RNA replication
• Chain: A
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 3.4.22.46: L-peptidase.
  3.6.1.15: nucleoside-triphosphate phosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	R17 L108 D109 T115 A116 F162 K164 V181 H204 G216 C217 N218 S298 G299 C300 S301 T303 Y336	R17 L108 D109 T115 A116 F162 K164 V181 H204 G216 C217 N218 S298 G299 C300 S301 T303 Y336
BS02	rna	A	Y336 D338 L386 K387 I411 R416 E422 K423 S426	Y336 D338 L386 K387 I411 R416 E422 K423 S426
BS03	MG	A	D238 D339	D238 D339
BS04	UTP	A	K164 R179 D245 S298 D338	K164 R179 D245 S298 D338

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity

Biological Process

• GO:0006351 DNA-templated transcription
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:2e9z, PDBe:2e9z, PDBj:2e9z
• PDBsum: 2e9z
• PubMed: 17517631
• UniProt: Q9QCE4