Structure of PDB 2e94 Chain A

Receptor sequence
>2e94A (length=303) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TKNKMEAKIDELINNDPVWSSQNESLISKPYNHILLKPGKNFRLNLIVQI
NRVMNLPKDQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGV
PSTINTANYMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDI
YWRDFLPEIIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSSGHSLVPFI
NLLGIIYQIRDDYLNLKDFQMSSEKGFAEDITEGKLSFPIVHALNFTKTK
GQTEQHNEILRILLLRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNM
IKN
3D structure
PDB2e94 Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
ChainA
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.-
2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
2.5.1.29: geranylgeranyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D80 D84 D79 D83
BS02 364 A V69 H73 D80 R89 L178 F179 Y210 Q211 K238 V68 H72 D79 R88 L177 F178 Y207 Q208 K235 PDBbind-CN: -logKd/Ki=8.00,Ki=0.01uM
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004311 farnesyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0015031 protein transport
GO:0016114 terpenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0033386 geranylgeranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2e94, PDBe:2e94, PDBj:2e94
PDBsum2e94
PubMed17535895
UniProtQ12051|GGPPS_YEAST Geranylgeranyl pyrophosphate synthase BTS1 (Gene Name=BTS1)

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