Structure of PDB 2e8u Chain A

Receptor sequence
>2e8uA (length=288) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
NKMEAKIDELINNDPVWSSQNESLISKPYNHILLKLNLIVQINRVMNLPK
DQLAIVSQIVELLHNSSLLIDDIEDNAPLRRGQTTSHLIFGVPSTINTAN
YMYFRAMQLVSQLTTKEPLYHNLITIFNEELINLHRGQGLDIYWRDFLPE
IIPTQEMYLNMVMNKTGGLFRLTLRLMEALSPSHSLVPFINLLGIIYQIR
DDYLNLKDFQMSFAEDITEGKLSFPIVHALNFTKTKGQTEQHNEILRILL
LRTSDKDIKLKLIQILEFDTNSLAYTKNFINQLVNMIK
3D structure
PDB2e8u Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases
ChainA
Resolution2.08 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.-
2.5.1.1: dimethylallyltranstransferase.
2.5.1.10: (2E,6E)-farnesyl diphosphate synthase.
2.5.1.29: geranylgeranyl diphosphate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D80 D84 D71 D75
BS02 MG A D80 D84 D71 D75
BS03 IPE A K38 H73 R90 Y210 K35 H64 R81 Y197
BS04 IPE A D80 R89 D214 K238 D71 R80 D201 K221
Gene Ontology
Molecular Function
GO:0004161 dimethylallyltranstransferase activity
GO:0004311 farnesyltranstransferase activity
GO:0004337 geranyltranstransferase activity
GO:0004659 prenyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0008299 isoprenoid biosynthetic process
GO:0015031 protein transport
GO:0016114 terpenoid biosynthetic process
GO:0033384 geranyl diphosphate biosynthetic process
GO:0033386 geranylgeranyl diphosphate biosynthetic process
GO:0045337 farnesyl diphosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2e8u, PDBe:2e8u, PDBj:2e8u
PDBsum2e8u
PubMed17535895
UniProtQ12051|GGPPS_YEAST Geranylgeranyl pyrophosphate synthase BTS1 (Gene Name=BTS1)

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