Structure of PDB 2e5w Chain A

Receptor sequence
>2e5wA (length=280) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence]
MRDMEFIEWYPRGYGVAFKVKRKILEEQSEYQKIEVYETEGFGKLLAIDG
TVQLVTEGEKSYHEPLVHPAMLAHPNPRRVLIIGGGDGGAIREVLKHEEV
EEVIMVEIDKKVIEISAKYIGIDGGILEKMLSDKHEKGKLIIGDGVKFIE
ENSGFDVIIVDSTDPVGPAEMLFSEEFYKNAYRALNDPGIYVTQAGSVYL
FTDEFLTAYRKMRKVFDKVYYYSFPVIGYASPWAFLVGVKGSIDFMKVDA
EKGKKLGLEYYDPDKHETLFQMPRYIVQML
3D structure
PDB2e5w Crystal structure of spermidine synthase from Pyrococcus horikoshii OT3
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AG3 A E8 V52 Q53 Y62 H63 D87 D161 S162 D164 Q194 Y229 W233 E8 V52 Q53 Y62 H63 D87 D161 S162 D164 Q194 Y229 W233
BS02 MTA A G84 G85 E107 I108 V112 D144 G145 S162 P168 A169 L172 G84 G85 E107 I108 V112 D144 G145 S162 P168 A169 L172
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0008295 spermidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2e5w, PDBe:2e5w, PDBj:2e5w
PDBsum2e5w
PubMed
UniProtO57950|SPEE_PYRHO Polyamine aminopropyltransferase (Gene Name=speE)

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