Structure of PDB 2e59 Chain A

Receptor sequence
>2e59A (length=144) Species: 9606 (Homo sapiens) [Search protein sequence]
EAQKQYWVCNSSDASISYTYCDKMQYPISINVNPCIELKGSKGLLHIFYI
PRRDLKQLYFNLYITVNTMNLPKRKEVICRGSDDDYSFCRALKGETVNTT
ISFSFKGIKFSKGKYKCVVEAISGSPEEMLFCLEFVILHQPNSN
3D structure
PDB2e59 Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa
ChainA
Resolution2.21 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LP5 A F76 F104 F119 S120 F60 F88 F103 S104
BS02 LP4 A I52 S120 F121 K122 I124 I36 S104 F105 K106 I108
Gene Ontology
Molecular Function
GO:0001530 lipopolysaccharide binding
GO:0035662 Toll-like receptor 4 binding
Biological Process
GO:0045087 innate immune response

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2e59, PDBe:2e59, PDBj:2e59
PDBsum2e59
PubMed17569869
UniProtQ9Y6Y9|LY96_HUMAN Lymphocyte antigen 96 (Gene Name=LY96)

[Back to BioLiP]