Structure of PDB 2e4w Chain A

Receptor sequence
>2e4wA (length=518) Species: 10116 (Rattus norvegicus) [Search protein sequence]
RREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEI
NKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLIPLLIAGVIGGS
YSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAK
AMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGR
SNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAANRVNASFTWVA
SDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNP
WFRDFWEQKFQCSLQNKRNHRQVCDKHLAIDSSNYEQESKIMFVVNAVYA
MAHALHKMQRTLCPQTTKLCDAMKILDGKKLYKEYLLKIQFTAPFNPNKG
ADSIVKFDTFGDGMGRYNVFNLQQTGGKYSYLKVGHWAETLSLDVDSIHW
SRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDC
GPGQWPTADLSGCYNLPE
3D structure
PDB2e4w Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 C5A A R64 R68 S149 S151 A172 S173 T174 Y222 D301 G302 K389 R35 R39 S100 S102 A123 S124 T125 Y173 D252 G253 K340
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2e4w, PDBe:2e4w, PDBj:2e4w
PDBsum2e4w
PubMed17360426
UniProtP31422|GRM3_RAT Metabotropic glutamate receptor 3 (Gene Name=Grm3)

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