Structure of PDB 2e3x Chain A

Receptor sequence

>2e3xA (length=416) Species: 343250 (Daboia siamensis)

QFNKIFIELVIIVDHSMAKKCNSTATNTKIYEIVNSANEIFNPLNIHVTL
IGVEFWCDRDLINVTSSADETLNSFGEWRASDLMTRKSHDNALLFTDMRF
DLNTLGITFLAGMCQAYRSVGIVQEQGNRNFKTAVIMAHELSHNLGMYHD
GKNCICNDSSCVMSPVLSDQPSKLFSNCSIHDYQRYLTRYKPKCIFNPPL
RKDIVSPPVCGNEIWEEGEECDCGSPANCQNPCCDAATCKLKPGAECGNG
LCCYQCKIKTAGTVCRRARDECDVPEHCTGQSAECPRDQLQQNGKPCQNN
RGYCYNGDCPIMRNQCISLFGSRANVAKDSCFQENLKGSYYGYCRKENGR
KIPCAPQDVKCGRLFCLNNSPRNKNPCNMHYSCMDQHKGMVDPGTKCEDG
KVCNNKRQCVDVNTAY

3D structure

• PDB: 2e3x Crystal structure of RVV-X: an example of evolutionary gain of specificity by ADAM proteinases.
• Chain: A
• Resolution: 2.91 Å

Enzymatic activity

• Enzyme Commision number: 3.4.24.58: russellysin.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	H145 H149 H155	H139 H143 H149
BS02	CA	A	E14 D96 C200	E8 D90 C194
BS03	CA	A	V215 N218 I220 E222 E225 D228	V209 N212 I214 E216 E219 D222
BS04	CA	A	D279 V280 E282 D294 Q295	D273 V274 E276 D288 Q289
BS05	CA	A	N51 E219	N45 E213
BS06	GM6	A	N109 T110 L111 H145 E146 H149 H155 P171 V172 L173	N103 T104 L105 H139 E140 H143 H149 P165 V166 L167

Gene Ontology

Molecular Function

• GO:0004222 metalloendopeptidase activity
• GO:0008237 metallopeptidase activity

Biological Process

• GO:0006508 proteolysis

External links

• PDB: RCSB:2e3x, PDBe:2e3x, PDBj:2e3x
• PDBsum: 2e3x
• PubMed: 18060879
• UniProt: Q7LZ61|VM3CX_DABSI Coagulation factor X-activating enzyme heavy chain