Structure of PDB 2e2r Chain A

Receptor sequence

>2e2rA (length=227) Species: 9606 (Homo sapiens) [Search protein sequence]

KPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIG
WAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYI
MDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMH
IEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKA
VQHFYNIKLEGKVPMHKLFLEMLEAKV

3D structure

PDB

2e2r Structural Evidence for Endocrine Disruptor Bisphenol A Binding to Human Nuclear Receptor ERR{gamma}

Chain

Resolution

1.6 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	2OH	A	L268 E275 M306 L309 Y326 N346 I349 F435 V458	L37 E44 M75 L78 Y95 N115 I118 F204 V227	MOAD: Kd=5.5nM PDBbind-CN: -logKd/Ki=8.26,Kd=5.5nM BindingDB: IC50=13.1nM

External links

PDB	RCSB:2e2r, PDBe:2e2r, PDBj:2e2r
PDBsum	2e2r
PubMed	17761695
UniProt	P62508\|ERR3_HUMAN Estrogen-related receptor gamma (Gene Name=ESRRG)

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