Structure of PDB 2e26 Chain A

Receptor sequence

>2e26A (length=705) Species: 10090 (Mus musculus)

VLLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEVG
EHSITTRDLSVNENTIIQFEINVGCSTDSSSADPVRLEFSRDFGATWHLL
LPLCYHSSSLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVR
FRWYQGFYPAGSQPVTWAIDNVYIGPQCEEMCYGHGSCINGTKCICDPGY
SGPTCKISTKNPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLF
FNEDGLRMLVTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNG
GLSWSLLQEFLFSNSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHFYS
PWVIDQILIGGNISGNTVLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDAL
VFIEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSCYAIELEYSVDLG
LSWHPLVRDCLPTNVECSLQRILVSDTFNKWTRITLPLPSYTRSQATRFR
WHQPAPFDKQQTWAIDNVYIGDGCLDMCSGHGRCVQGSCVCDEQWGGLYC
DEPETSLPTQLKDNFNRAPSNQNWLTVSGGKLSTVCGAVASGLALHFSGG
CSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNRNQGVLLEYSVNGGITWN
LLMEIFYDQYSKPGFVNILLPPDAKEIATRFRWWQPRHDGLDQNDWAIDN
VLISR

3D structure

• PDB: 2e26 Structure of a receptor-binding fragment of reelin and mutational analysis reveal a recognition mechanism similar to endocytic receptors.
• Chain: A
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	N2522 N2524 S2549 L2551 D2657	N564 N566 S591 L593 D699
BS02	CA	A	D2173 E2175 N2202 D2310 Q2311	D218 E220 N247 D355 Q356
BS03	ZN	A	E2397 E2399 H2460	E442 E444 H502
BS04	CA	A	D2327 T2351 D2353 D2474	D372 T396 D398 D516
BS05	CA	A	T1961 D1963 E1993 S1995 D2125	T6 D8 E38 S40 D170
BS06	ZN	A	H2061 H2074 E2264	H106 H119 E309

Gene Ontology

Molecular Function

• GO:0070325 lipoprotein particle receptor binding

Biological Process

• GO:0001764 neuron migration
• GO:0007417 central nervous system development

External links

• PDB: RCSB:2e26, PDBe:2e26, PDBj:2e26
• PDBsum: 2e26
• PubMed: 17548821
• UniProt: Q60841|RELN_MOUSE Reelin (Gene Name=Reln)